Actor George Clooney, who has worked with Pitt closely in "Ocean's Eleven" and its sequels, told eonline.com: "I didn't know that. I feel very sorry then. That's a sad story and unfortunate for a family. It's an unfortunate story about a family. I feel very sorry to hear that." 

Oscar winning songstress Adele, who was performing at a concert in New York, said: "I'm dedicating this show tonight to them, I was shocked when I woke up this morning."

Here are some of the reactions the celebrities gave on the split of Hollywood's A-list couple:

Alyssa Milano: WTF? Brad and Angelina?!. I'm crushed.

Emily Blunt: It's their business, and it's not for anybody else to comment on.

Luke Evans: It's very sad to hear.

Chrissy Teigen: Brad and Angelina. How am I supposed to go to work today? 

Questlove: Everyone is serious as a heart attack with this 'I might actually have a chance! Talk Brangelina.

Josh Gad: Before we get too cavalier about it, let's remember that Brangelina was possibly the only thing still holding the USA together.

Colin Jost: Holy shit someone explain this Jolie-Pitt divorce in terms of skittles because I don't understand it.

Spencer Pratt: I feel bad for kids that aren't gonna get adopted by Brangelina now.

Patton Oswalt: Tower of Terror! Eggo! Skittles! Brad Pitt! I don't know why any of them are trending, but I'm running to my basement. It's over.

Boy George: It's sad about Brad and Angelina, but it's also none of our business!